Python Using GPT-5 and Gemini provides a practical, up-to-date guide that combines solid Python programming skills with real-world integration of today’s leading large language models. The book teaches essential Python techniques while showing readers exactly how to connect and use GPT-5, Google Gemini, Claude, Grok, Perplexity, and other major models in their daily work. Readers will gain a strong foundation in Python data structures, comprehensions, generators, regular expressions, and object-oriented programming. The book then moves into detailed coverage of GPT-5 (including GPT-5.4 and GPT-5.3 Instant), Gemini 3.1, Claude Mythos and Opus 4.6, along with practical Python code samples for chatbots, tool calling, data analysis, graphics generation, and integration with PowerPoint and Excel. Additional chapters explore LLM benchmarks, deceptive behaviors such as alignment faking and scheming, military AI applications, and comparisons between the major models, giving readers clear insight into their relative strengths and limitations. This book is written for intermediate Python developers, data scientists, technical professionals, and anyone who wants to move beyond basic prompting and build production-ready applications that effectively combine Python with the latest generation of large language models.